Company research projects supported by PIPE Program

Biobreyer Pesquisa e Desenvolvimento Científico Ltda

City: Santos

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Research grants

Ongoing (most recent)

Abstract
Hyaluronic Acid (HA) is a biopolymer widely used in the cosmetic, healthcare, and dietary supplement industries due to its moisturizing and regenerative properties. This project aims to scale up the production of HA using genetically modified Kluyveromyces lactis yeast, aiming to reduce dependency on imports and meet the growing demand with a high-quality and sustainable product. During t…
Scaling Up the Production Process of Hyaluronic Acid Produced by Recombinant Kluyveromyces lactis, AP.PIPE
Abstract
The global pharmaceutical market generates approximately $1 trillion annually, with an estimated target of reaching $1.5 trillion by 2023. Among pharmaceutical products, significant attention is given to those produced through biotechnological routes, primarily represented by medications used in the treatment of cancer, Alzheimer's disease, cardiovascular diseases, among others. In Brazil…
Production of pilot batches in GLP and non-clinical studies of a new PEG conjugated Asparaginase for the treatment of neoplasias, AP.PIPE

Completed (most recent)

Abstract
The Hyaluronic Acid (HA) is a biopolymer composed of alternating repetitions of glucuronic acid (GlcUA) and N-acetyl glucosamine (GlcNAc) and is present in all vertebrates. According to projections performed by the company "Grand View Research", the global HA market was valued at 10.80 billion dollars in 2020 and is projected to be a compound annual growth of 8.1%, in addition to reaching…
Hyaluronic acid production for therapeutic and cosmetic use by biotechnological process using recombinant Kluyveromyces lactis yeast, AP.PIPE
Abstract
Asparaginase (ASNase) is an enzyme used to treat lymphatic system cancers, especially Acute Lymphoblastic Leukemia (ALL). The ASNase administration can promote adverse effects in the patients, including immunological responses, allergic reactions, and anaphylactic shock. In these cases, treatment with other ASNase formulations is possible, however there are still adverse responses in many…
Development of a new PEG conjugated asparaginase for treatment of neoplasias, AP.PIPE
Abstract
Biopharmaceuticals are biological drugs used in the cancer, diabetes, cardiovascular diseases treatment. In Brazil, there is a great deficiency of biopharmaceuticals production. According to the Brazilian Pharmochemical Industry Association Index of 2016, about 4% of the medicines purchased by the Ministry of Health are biopharmaceuticals, however this drugs represents about 51% of expens…
Development of a new PEG conjugated asparaginase for the neoplasias treatment, AP.PIPE